PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
-
PROTAC Linkers Related Products (4103)
Related Products (4103)
-
PROTAC Linkers Isoform Comparison
-
BG-PEG4-DBCO
0 ImagesCat. No.: HY-W1130311
-
tert-Butyl 4-chlorobutanoate
0 ImagesCat. No.: HY-W069230CAS No.: 3153-32-0
-
bis (Boc-Azetidine)
0 ImagesCat. No.: HY-W837047CAS No.: 2757731-43-2
-
2-(2-Bromoethoxy)ethan-1-amine
0 ImagesCat. No.: HY-W792642CAS No.: 471910-67-5
-
Docosanedioic acid (Standard)
0 ImagesCat. No.: HY-W034918RCAS No.: 505-56-6Docosanedioic acid (Standard) is the analytical standard of Docosanedioic acid (HY-W034918). This product is intended for research and analytical applications. Docosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Docosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
-
tert-Butyl 4-(4-(aminomethyl)benzoyl)piperazine-1-carboxylate
0 ImagesCat. No.: HY-W145021CAS No.: 1299397-08-2
-
(9H-fluoren-9-yl)methyl (5-aminopentyl)carbamate hydrochloride
0 ImagesCat. No.: HY-W275631CAS No.: 177333-17-4
-
3-(Piperidin-4-yl)propan-1-ol hydrochloride
0 ImagesCat. No.: HY-W611636CAS No.: 155270-01-2
-
Hydroxy-PEG7-C2-COOH
0 ImagesCat. No.: HY-W190779CAS No.: 1797408-46-8
-
Benzyl (5-aminopentyl)carbamate hydrochloride
0 ImagesCat. No.: HY-W129178CAS No.: 18807-74-4
-
Benzyl hex-5-yn-1-ylcarbamate
0 ImagesCat. No.: HY-W822795CAS No.: 1446257-54-0
-
Cbz-NH-C2-PEG3-Br
0 ImagesCat. No.: HY-W793322CAS No.: 2678597-39-0
-
4-(4-Cyanobenzyl)piperidine, HCl
0 ImagesCat. No.: HY-W156885CAS No.: 333987-04-5
-
Benzyl 3-(2-bromoethyl)azetidine-1-carboxylate
0 ImagesCat. No.: HY-W822059CAS No.: 1420894-87-6
-
NH2-PEG-C2-methanamine
0 ImagesCat. No.: HY-W184476CAS No.: 1525892-92-5
-
19-Bromononadecanoic acid
0 ImagesCat. No.: HY-W105738CAS No.: 78774-38-6
-
Potassium 6-hydroxyhexanoate
0 ImagesCat. No.: HY-W105753CAS No.: 21810-34-4Synonyms: 6-Hydroxyhexanoic acid, potassium salt
-
[1,4′-Bipiperidine]-ethyl formate dihydrochloride
![[1,4′-Bipiperidine]-ethyl formate dihydrochloride](https://file.medchemexpress.com/product_pic/hy-w098985.gif "Click to View [1,4′-Bipiperidine]-ethyl formate dihydrochloride Product Detail")
0 ImagesCat. No.: HY-W098985CAS No.: 930604-29-8
